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4 Current therapeutic landscape and unmet need While resmetirom (a THR- agonist) has recently gained FDA approval for the treatment of MASH (in patients with fibrosis F2-F3), marking the first-ever pharmacological agent for this condition (Liu et al., 2025), there remains no single FDA-approved drug that effectively prevents or reverses the progression of advanced SLD to HCC

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Another common side effect associated with GLP-1 agonists is headaches