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The New England journal of medicine, 387(3), 205216

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Hepatic clearance accounts for roughly 25% of total apixaban elimination, primarily through CYP3A4 with minor contributions from CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2J2 [2]

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Fortunately, there are safe, natural, and effective ways to manage GLP-1-induced constipation , especially when viewed through the lens of functional and integrative medicine

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