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The primary reasons for exclusion were withdrawal from follow-up at the participants discretion, treatment discontinuation due to nausea, drug supply issues, cholangiocarcinoma, pancreatitis, and treatment cessation at a non-participating institution ( Figure 1 )

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Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes: The CAROLINA Randomized Clinical Trial