Most experts say up to 500 mg per day for a couple of months is generally well tolerated.
Five metabolites (betaine, L-acetylcarnitine, L-carnitine, ribonic acid, and glucaric acid) increased and three metabolites (uridine, taurine, and glutathione) significantly decreased in the aqueous humor of glaucoma patients (Fig
"A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study." JANA 11 (2008): 50-56
Assuming the above, the researcher may administer DSIP via nasal spray as follows: DSIP Dosage: A total daily dose of 300mcg, with 150mcg administered in each nostril in three sprays of 50mcg each, may be applied