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ALX-0171 a trivalent nanobody targeting the fusion protein of respiratory syncytial virus achieves efficient deposition in the lower respiratory tract, potently neutralizing respiratory syncytial virus at early stages of infection and reducing viral replication in preclinical models 238,239

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Enzymes that produce ROS, including ALOX, xanthine dehydrogenase, NADPH oxidase, and the mitochondrial electron transport chain complex, bind to iron, heme, or iron-sulfur clusters

First, as adjuncts to standard care, selected strains or formulationssuch as Escherichia coli Nissle 1917, VSL#3, and certain multi-strain probioticsprovide additive or synergistic benefits, improving key outcomes including clinical response, endoscopic remission, and health-related quality of life (HRQoL