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Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology

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Elevated zonulin levels have been found in patients with rheumatoid arthritis, multiple sclerosis or ankylosing spondylitis [1, 73,74,75]

Recent investigations have pioneered three critical advancements in diabetic peripheral neuropathy (DPN) research: (1) systematic elucidation of ncRNA regulatory mechanisms through exosome-mediated transcellular signaling (eg, miR-146a-5p nanoparticles enhancing nerve repair), (2) integration of multi-omics technologies to decode epigenetic-metabolic networks, and (3) development of nanotherapeutic strategies enabling diagnosis-to-treatment synergy