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The combination of myo-inositol and metformin demonstrated clear clinical benefits in women with PCOS undergoing induction cycles (80)

GLP-1 agonists are being used in combination with basal insulin (Dungan & DeSantis, 2016), although this is not an FDA-approved indication (see rxlist.com) they should not be used as a substitute for basal insulin, as this has been found to result in a decline in glycemic control)(Dungan & DeSantis, 2016) Clinical trials indicate it can reduce HbA1c by ~0.8% Undergoes renal clearance, with dosage reduction needed if creatinine clearance falls to 1.5

Patients should be advised to seek medical evaluation for concerning symptoms such as new or progressive proximal weakness, frequent falls, inability to rise from a chair without assistance, severe muscle cramps with dark urine, or prolonged poor nutritional intake

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