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Enter the dynamic duo of Semaglutide and Tirzepatide

When you take semaglutide GLP-1, it signals your brain to feel fuller faster and reduces hunger, which naturally leads to eating fewer calories

GLP-1R agonists reach reward circuits, hinting at use in substance disorders

Abbreviations ASC: Apoptosis speck-like protein -SMA: -smooth muscle actin BLM: Bleomycin ECM: Excessive extracellular matrix F-6-P: Fructose-6-phosphate F-1, 6-BP: Fructose-1, 6-bisphosphate F-2, 6-BP: Fructose-2, 6-bisphosphate Fn: Fibronectin GLP-1R: Glucagon-like peptide-1 receptor GSDMD: Gasdermin D IPF: Idiopathic pulmonary fibrosis IL-18: Interleukin 18 IL-1: Interleukin 1 NLRP3: Nucleotide-binding and oligomerization domain, leucine-rich repeat, and pyrin domain-containing 3 Pan-Kla: Pan-histone lysine lactylation PFK1: 6-phosphofructo-1-kinase PFKFB3: 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 TNF-: Tumor necrosis factor TGF-1: Transforming growth factor 1 References Perrot CY, Karampitsakos T, Herazo-Maya JD