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In the canonical GPX4-dependent pathway, p53 suppresses SLC7A11 to reduce cystine uptake, leading to GSH depletion and impaired GPX4 activity, thereby promoting ferroptosis
[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Softic S., Gupta M.K., Wang G.-X., Fujisaka S., ONeill B., Rao T.N., Willoughby J., Harbison C., Fitzgerald K., Ilkayeva O., et al
Because DHEA is only converted into sex steroids in target tissues containing the relevant physiologic enzymatic machinery, it has been suggested that it could be used for treating estrogen-deficient wound healing without deleterious systemic side effects (Pomari et al., 2015)
The inflammatory response in myocardial infarction
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