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FOXO4-p53 Disruption Moderate Research Detailed mechanistic studies confirm that FOXO4-DRI achieves its senolytic effects through precise disruption of the protective FOXO4-p53 protein interaction that allows senescent cells to evade apoptosis and persist in tissues

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To assess the effects of BHBA on intracellular Ca 2+ levels, hippocampal neurons were loaded with the calcium-sensitive fluorescence indicator Fluo-4AM, and the changes in fluorescence intensity were measured in all cell bodies of neurons (Figure 3A)