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SGLT-2is can increase the excretion of urinary glucose by inhibiting SGLT-2 transporters in proximal renal tubules ( Hypoglycaemia is a common complication of T2DM, and its risk is an important principle for evaluating the safety of treatment options in current diabetes guidelines

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Clinical trial data suggests comparable GI side effect profiles, though some patients who cannot tolerate one medication do better on the other due to individual receptor sensitivity differences