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Products may contain impurities, synthesis byproducts, or fillers that can lead to allergic reactions or toxicity, she says

And honestly, for most people, that probably means taking reasonable doses, timing them well, making sure you have adequate folate and other supporting nutrients, and checking in with your healthcare provider periodically to make sure everythings on track.

"Dietary supplements and weight control in a middle-age population"

An early analysis of the results of 12 randomized controlled trials showed that folic acid supplementation (0.5-5 mg/day) had the greatest lowering effect on blood homocysteine concentrations (25% decrease)