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IGF-I administered to GH deficient rats (or to patients with GH receptor defects) normalizes the low GFR as does GH replacement in GH deficiency

[12] [13] Their side effects are well documented and generally mild (headache, flushing, nasal congestion, dyspepsia)

The figure illustrates how specific microbial metabolites and defined microbial taxa, rather than overall microbial diversity, contribute to braingut communication through GLP-1-mediated neuroendocrine signaling pathways

Synthetic GH (like HGH injections) provides exogenous hormone that can suppress natural production and carries higher risks of side effects