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Acknowledgements The authors extend their appreciation to the Deanship of Research and Graduate Studies at King Khalid University for funding this work through a Large Research Project under grant number RGP2/580/45

Fractional lasers therefore occupy a distinct place in the non surgical facelift pathway: they restore dermal structure, clarify the surface and enhance the way the face reflects light, all while maintaining a short and predictable recovery period

545,546 Patients with DPN are also at an increased risk of falls due to sensory loss, balance impairment, and muscle weakness

Increased expression of DAF-16, the ortholog of human FoxO proteins in the worm Caenorhabditis elegans , due to a mutation of the insulin/IGF-1 receptor daf-2 has been found to significantly increase the worm's lifespan [2, 3]