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The peptide retains activity in human gastric juice for more than 24 hours, tolerates pH from 1 to 11, and resists multiple proteolytic enzymes, properties that derive from the high proline content (four of fifteen residues) and the absence of cleavage-prone motifs
Some researchers have found that miR-382-5p expression is down-regulated and SLC7A11 expression is up-regulated in ovarian cancer tissues, and lidocaine targets the miR-382-5p/SLC7A11 axis (which up-regulates miR-382-5p expression and down-regulates SLC7A11 expression) to promote ferroptosis in ovarian cancer cells and exert anti-tumor activity (97)