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4, 5, 6, 7 GIP is secreted from K cells in the proximal small bowel and binds to GIP receptors expressed by pancreatic islet cells, as well as to receptors in adipose tissue and the brain

Altered Insulin receptor substrate 1 phosphorylation in blood neuron-derived extracellular vesicles from patients with Parkinsons disease

P.PardoV.RuizL.Castro-S AnchezL.LanzB.Fern Andez-MillE.et al (2016)

Paul Coates, former director of the Office of Dietary Supplements at the National Institutes of Health, reviewed many of the scientific studies on Protandim, including the one demonstrating a 7% increase in lifespan for male mice, and said he found them to be largely well designed, if small in scope