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Certain medical conditions and medications increase B12 requirements: Long-term use of metformin (diabetes medication) or proton pump inhibitors (PPIs for acid reflux) can impair B12 absorption [13] [14] Gastrointestinal conditions such as Crohn's disease, coeliac disease, or previous gastric surgery Autoimmune conditions beyond pernicious anaemia may affect B12 metabolism When to contact your GP : If you are taking B12 supplements or receiving injections but continue to experience symptoms, request a review

We understand that a variety of factors can affect the duration of the Vitamin B12 shots efficacy

MMA accumulates in the blood when B12-dependent metabolic reactions stall

Further, it activates muscle stem cells, promoting tissue regeneration, and reverses insulin resistance in relevant animal models, all with good systemic tolerability 1,2