A 2026 follow-up study showed a similar boost for tirzepatide, where women pairing the drug with HRT achieved a 19% weight reduction compared to 14% for those taking the medication alone
PubMed , Huidekoper, Hidde H., et al
20(1):6186 Stefanakis K, Kokkorakis M, Mantzoros CS (2024) The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation
Data from our laboratory ( Effect of the microbiome The gut microbiome consists of trillions of microorganisms that contribute to the host digestive system, generating metabolites of which the short-chain fatty acids (SCFAs): acetate, propionate and butyrate, are primary components, produced through the fermentation of indigestible polysaccharides (ODonnell et al., 2023)