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Below BMI 27, youre in the overweight or normal category where the health impacts of excess weight are less clear and the benefit-risk calculation for medication is less favorable

This reparative effect is mediated, at least in part, through the upregulation and reorganization of key regulatory proteins, most notably protein kinase C (PKC) and the tight junction scaffolding protein zonula occludens-2 (ZO-2), thereby facilitating the reassembly and functional recovery of the tight junction complex (161)

Sci American

MMPs are zinc-dependent enzymes that break down extracellular matrix components like collagen and elastin