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The SELECT trial data showing 20% reduction in MACE makes semaglutide the only compound in this class with proven cardiovascular benefit

Long-term acid reflux can lead to irritation or damage to the esophagus

FEBS Lett 425:528529 Foyer CH, Souriau N, Perret S, Lelandais M, Kunert KJ, Pruvost C, Jouanin L (1995) Overexpression of glutathione reductase but not glutathione synthetase leads to increases in antioxidant capacity and resistance to photoinhibition in poplar trees

While this is often beneficial for those with high blood pressure, it may lead to dizziness or lightheadedness in those who already have low blood pressure or who receive high-dose intravenous treatments