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Common Symptoms of MCAS Because mast cells exist in nearly every tissue, MCAS can cause a wide range of symptoms, including: Skin issues: Hives, flushing, itching, eczema Digestive problems: Bloating, acid reflux, nausea, diarrhea Neurological symptoms: Brain fog, anxiety, depression, migraines Respiratory issues: Wheezing, sinus congestion, shortness of breath Cardiovascular symptoms: Heart palpitations, low blood pressure, dizziness Muscle and joint pain: Inflammatory responses causing discomfort Symptoms often fluctuate in severity and can be triggered by certain foods, stress, environmental toxins, infections, or hormonal changes