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Clostridium butyricum protects the epithelial barrier by maintaining tight junction protein expression and regulating microflora in a murine model of dextran sodium sulfate-induced colitis

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Concurrently, TNF- and TGF-1 drive CSMC apoptosis and fibroblast-like phenotypic transformation, resulting in cavernous fibrosis and reduced tissue distensibility, while inflammatory cytokines and excessive ROS impair penile nerve integrity and neurotransmitter release, exacerbating neurogenic ED in animal studies (205)

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