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A historical perspective of transcriptional co-activators Co-activators, the essential components of cellular functioning, are known to modulate development, cell differentiation, maintenance of stem cells, aging, and their active involvement was recorded in developmental defects, metabolic disorders, and cancer

Early-life adversity may be particularly relevant because it can produce long-lasting alterations in stress responsivity and physiological homeostasis across the lifespan (Smith and Pollak, 2020)

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