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Summary: GLP-1 hormone is primarily produced by specialised L-cells located in the distal small intestine (ileum) and colon, with the highest concentrations in the ileum and large intestine

Oliveira Filho JP, Badial PR, Cunha PH, Cruz TF, Araujo JP, Divers TJ, Winand NJ, Borges AS: Cloning, sequencing and expression analysis of the equine hepcidin gene by real-time PCR

In the process, GLP-1s became one of the most consequential pharmaceutical breakthroughs in history

Appropriate Rate of Weight Loss Target: 0.5-1% of body weight per week maximum While GLP-1s can drive faster weight loss, slower is better for muscle preservation