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Genomic sections displaying sequence conservation over time within a single viral species or evolutionary conservation between members of the coronavirus family despite high mutation rates are indicative of essential regions of the viral genome that are functionally constrained, such as the fusion peptide within the spike S2 region [68, 69]
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This SLR identified only one study formally assessing treatment sequencing (RECAP), in which no significant difference in kidney outcomes was observed, based on whether SGLT2i or GLP-1 RA therapy was initiated first [17]
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