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In Fenton and Fenton-like reactions, divalent iron reacts with hydrogen peroxide to generate hydroxyl radicals, a primary source of radical formation [12]

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Our previous study using intestine-specific Zip14 KO (IKO) mice revealed that intestinal ZIP14 mediates basolateral uptake of Mn from the bloodstream into enterocytes, contributing to Mn excretion into the intestinal lumen ( 54 Mn was administered subcutaneously, intestinal radioactivity was significantly lower in IKO mice compared to controls, indicating impaired basolateral-to-apical Mn transport

Cell Signal 26 (3), 512520