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While glutathione is a powerful antioxidant and theoretically could reduce oxidative stress in melanocytes, there is no robust clinical data showing that increasing dietary or supplemental glutathione can reliably prevent or reverse gray hair in humans. The bodys regulation of hair pigmentation is complex, he added, and once melanocytes lose their ability to produce pigment, antioxidants alone are unlikely to restore it

Cape San Juan Press, 13 July 2017.

Despite the early termination of the trial, it is interesting to note that 13 of 140 patients had a median duration of response of 10.2 months, indicating that these patients benefited from combination therapy and that exploring the mechanisms of this benefit should be the focus of future research

Reshi et al., 2014)