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In patients with obesity, significant weight reduction achieved with GLP-1 therapy has been associated with improvements in sex hormone-binding globulin (SHBG) levels, reductions in free testosterone in women with hyperandrogenism, and normalization of menstrual cycles in some individuals with polycystic ovary syndrome (PCOS)

GHD also contributes to the alteration of body composition and weight gain, with decreased lean mass, increased FM, mainly truncal FM with increase waist/hip ratio, scarce muscle tone and strength, reduced energy expenditure, and exercise tolerance [45,46,47]

In addition, this enzyme possesses an N-terminal domain which cleaves Gro3P into glycerol and inorganic phosphate (Pi) (in humans and other organisms, this reaction is catalyzed by a separate glycerol-3-phosphate phosphatase, a reaction also known as glycerol shunt)