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The high GH levels, together with the often severe IGF-1 deficiency, will lead to a severe catabolic state, including significant lipolysis and proteolysis, comparable to extended fasting during a hunger strike, for instance [26]

[11] In one crossover study, patients with bipolar disorder on lithium were given either 15 mg or 300 mg of MB daily, and those on the higher dose experienced significantly less depression, suggesting efficacy at that dose, though side effects and long-term safety at such high doses remain concerns

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