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Effects on cognition and global function were evaluated with the Alzheimers Disease Assessment Scale Cognitive Subscale (ADAS-Cog) and the Clinician Interview-Based Impression of Change with Caregiver Input scale (CIBIC+) at 4, 12, and 24 weeks after the start of injections

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Report any new or unusual symptoms such as a neck lump, persistent hoarseness, or difficulty swallowing to your trial team promptly

Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13