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Moreover, the FDA-approved anticoagulant drug warfarin, a small-molecule inhibitor of VKORC1L1, suppresses tumor growth by inducing ferroptotic cell death in vivo, indicating that warfarin may be a potential anticancer drug, especially for cancer patients with high VKORC1L1 expression
Under conditions of compromised mitochondrial function, the PMF falls below the threshold required for ATP synthesis and the activity of ATP synthase can actually reverse such that it hydrolyzes ATP to pump protons back into the inner membrane space
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If we truly care about public health, we should stop asking whether patients are allowed to need long-term obesity treatment and start asking why we have not built a health care system that reliably provides it
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