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Functionally, cagrilintide activates amylin receptors AMY1R, AMY2R, AMY3R and the calcitonin receptor (CTR), binding via a conserved bypass motif involving mid-segment residues (S19 P25) (Cao et al

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Arrows added in purple to show the direction of gene changes for key enzymes involved in this pathway following melatonin treatment

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Cells were cultured in DMEM/F12 supplemented with 10% fetal bovine serum and 100 U/ml penicillin-streptomycin

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