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Both medications cause some lean mass loss, but the ratio of fat loss to lean mass loss appears to favor tirzepatide based on available body composition data from the SURMOUNT trials

PMID: 38009416

The following study, incorporating data from six trials with 49,875 participants assessing four SGLT2 inhibitors, revealed a reduction in serious hyperkalemia risk (1754 cases) with a hazard ratio of 0.84 (95% CI, 0.76-0.93)

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