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Biosynthesis and Hormonal Interactions L-carnitine plays a critical role in energy production by transporting fatty acids into mitochondria for oxidation

Despite their well-established antineoplastic efficacy, platinum-based agents have poor tumor selectivity, frequently causing acute adverse reactions such as acute kidney injury, myelosuppression, and gastrointestinal toxicities

Likewise, nanoparticles can be made to respond to enzymes that are derived from overexpressed tumour tissues or on internalization of the nanoparticle

Three primary E3 ligases are involved: RBX1 (RING-box protein 1), RBX2 [RING-box protein 2