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In the worst case, that can lead to heart failure

DiStasio, A

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it is an evolving aspirational treatment goal 14,15 normalisation of inflammatory markers (C-reactive protein [CRP] and faecal calprotectin) these noninvasive disease activity markers have been shown to correlate with endoscopic activity in UC and have an established role as surrogate indices 16 normal health-related quality of life improvement in quality of life may require additional measures, such as dietary and psychological therapies, as well as independent management of immune-mediated extraintestinal manifestations