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A recent retrospective cohort study found that patients with T2DM on GLP-1RAs experienced fewer asthma exacerbations compared to those on other anti-glycemic agents, having a comparative incidence rate ratio that covers the range of 1.83 to 2.98 [255]

This has led to clinical development of AS inhibitors Sodium/glucose cotransporter 2 (SGLT2) inhibitors are the standard of care in people with CKD with or without type 2 diabetes mellitus (T2DM) and may also mitigate potential hyperkalemia risk with AS inhibitors Vicadrostat is a highly selective AS inhibitor in clinical development for the treatment of CKD and heart failure

The compound's half-life of approximately 8-12 hours means that single daily doses maintain adequate tissue levels for sustained effects