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Patients with a clinically diagnosed B12 deficiency should be under GP care for ongoing management

This aging mechanism is closely related to various common diseases, including atherosclerosis, hypertension, chronic obstructive pulmonary disease, diabetes, and neurodegenerative disorders ( Current senolytic agents are primarily employed in cancer therapies, such as doxorubicin, trametinib, and cell cycle-targeting drugs like palbociclib ( Although studies have shown that FOXO4-DRI can block the binding of P53 to FOXO4, thereby promoting the apoptosis of senescent cells, the effect of FOXO4-DRI is not limited to alleviating the aging of certain organs

KPV appears to enter cells and downregulate pro-inflammatory signaling, including the NF-kB pathway that drives inflammatory gene expression (Dalmasso et al., Am J Physiol Gastrointest Liver Physiol, 2008)

Delta sleep-inducing peptide: structure-function relationships