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Nature 468 , 927932 (2010)

Subsequently, the receptor is taken up by endosomes, where it can either continue its signaling intracellularly, be recycled to the cell surface (resensitization) or undergo lysosomal degradation

As its absorption rate is higher you dont need them as frequently as the pills

This is more common in people with pre-existing digestive sensitivities, those taking high doses of other fiber supplements, or individuals whose baseline microbiome was significantly different from the profile Pendulum is trying to create