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Although the two drugs work through different mechanisms, they complement rather than duplicate each other

Several studies have reported pathological astrogliosis and associated neuronal hypotrophic glucose metabolism in patients with neurodegenerative disease and diabetic model animals, showing increased glial fibrillary acidic protein (GFAP) and significant cellular hypertrophy (32), which has been correlated to some extent with the severity of cognitive impairment in patients with Alzheimers disease (AD)

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10.1021/acs.molpharmaceut.2c00261 23 BeutheuS.GhouzaliI.GalasL.DechelotteP.CoeffierM