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Another meta-analysis (July 2025), looking only at endoscopies, found an increased incidence of pulmonary aspiration among patients taking GLP-1 RAs (OR 2.29, 95% CI 1.36-3.87)

A: This requires careful evaluation

doi: 10.1001/JAMAINTERNMED.2022.0338 114 McCleanPLGaultVAHarriottPHlscherC

Although lifestyle interventions (low-calorie diets and exercise) are still the cornerstone of weight management, weight loss achieved through this approach is extremely difficult to sustain in the long term, particularly due to physiological adaptations that reduce the energy expended or increase appetite to compensate for the missing calories