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In a 48-week Phase 2 trial published in the New England Journal of Medicine (Sanyal and colleagues, NCT04771273), 293 adults with biopsy-confirmed MASH and fibrosis stage F1 through F3 were randomized 1:1:1:1 to once-weekly subcutaneous survodutide at 2.4, 4.8, or 6.0 mg or placebo, again using a 24-week rapid escalation followed by a 24-week maintenance phase

Classified as a pentadecapeptide (15 amino acids), it functions as a signaling molecule in experimental models rather than an approved medical treatment

Hypothyroidism - an underactive thyroid is commonly associated with delayed intestinal transit time

What side effects are commonly reported