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GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) effectively manage type 2 diabetes and promote weight loss, but their gastrointestinal effectsincluding nausea, vomiting, and diarrheacan disrupt fluid and electrolyte balance

Protection against reactive oxygen species by selenoproteins

Given the intricate interplay between different cellular components, organelles, and pathways that regulate ferroptosis [107], it is imperative to consider the broader cellular context when evaluating ferroptosis triggers, modulators, and potential therapeutic interventions

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