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Meanwhile, microdose GLP-1s kickstart the action-motivation flywheel, enabling early successes by limiting food noise and creating space for healthier habits

As the newest addition to incretin-based drugs, tirzepatide harbors the potential to counteract most of the pathogenetic mechanisms underpinning CKD in T2D displaying unprecedented features in terms of glucose and weight lowering, accompanied by promotion of insulin sensitivity, control of SBP, dyslipidemia, and biomarkers of inflammation and endothelial dysfunction

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The severity depends on needle angle, injection depth, and individual vessel fragility