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Mechanistic validation revealed that the use of the mTOR activator MHY1485 reversed the anti-inflammatory effects of hydrogen, thereby confirming its regulation of microglial transformation via the mTOR-autophagy axis and providing molecular evidence for hydrogen therapy in sepsis-associated encephalopathy (SAE) (Zhuang et al., 2020)

Severe or prolonged dehydration can lead to acute kidney injury (AKI), a condition where the kidneys suddenly lose their filtering ability

References Abdelhamid AM, Selim A, Zaafan MA (2021) The hepatoprotective effect of piperine against thioacetamide-induced liver fibrosis in mice: the involvement of miR-17 and TGF-/smads pathways

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