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Compared with traditional opioids, remifentanil is suitable for short procedural analgesia rather than for ongoing analgesic needs, particularly during brief, intensely noxious procedures requiring rapid onset and offset with early recovery of spontaneous breathing, such as endotracheal intubation-surfactant-extubation (INSURE) or less-invasive surfactant administration (LISA) procedures, as well as brief invasive interventions (Tables 1, 2) (Figures 2, 3) (110115, 117119)

Modern approaches guided by genetic manipulations and medium supplementation have led to riboflavin overproduction in these organisms (Table 1)

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PMID 6895513)