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The 0.25 mg dose will reach lower peak concentrations compared to higher maintenance doses, but the time course for elimination follows the same pattern

Methods Cell culture, expression constructs, and transfection MIN-6 (purchased from ATCC) cells and GLUTag cells (obtained from Takashi Tsuboi, the university of Tokyo, Japan) were cultured in DMEM with 10% (v/v) heat-inactivated fetal bovine serum

This trial used two animal models of MS: the experimental autoimmune encephalomyelitis, EAE, model to mimic the autoimmune response and neurodegeneration in MS and the cuprizone, CPZ, model to mimic demyelination to nerve cells and to study remyelination of the damaged nerve cells in MS

doi: 10.1016/j.neuron.2009.11.013 121 KimJ.EltoraiA