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We've seen it time and again: promising research can be derailed by a lack of foundational knowledge

Four compounds, 55 58 , showed IC 50 values in the range of 26.30 to 55.00 nM, with 55 being the most active in the study, with the 4Cl substituent, and relatively comparable to the positive control, febuxostat, with an IC 50 of 6.91 nM (Figure 17)

Comparison: Branded vs

This gap is notable given the considerable variation in patient responses to therapy, suggesting that microbiota differences may partly contribute to, but have not yet been proven to determine, treatment outcomes