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"PRESS RELEASE: Lilly Sells Former ICOS Biologics Operation" (Press release)
Since kidney function is reduced during AKI, activation of the urea cycle and subsequent urea generation together lead to a substantial rise in BUN 14,35
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However, the administered NA dose was based on efficiency in hypercholesterolemia studies, therefore, an optimal NA dose for mitochondrial myopathy has to be determined, especially considering that another study found an association between metabolites of excess NA, 2PY, and 4PY, and cardiovascular disease (CVD) 245
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