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Managing Expectations: Hollowing, Sagging, and Facial Aesthetics Rapid facial fat loss can occasionally produce temporary hollowing or slight sagging, particularly in patients over 50 or those with pre-existing skin laxity

So youd have day 1 (what you call day 4) + another 2 days

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314 Further research on the mechanism of action of STAT6 in the treatment of UC is needed to obtain a comprehensive understanding of the therapeutic potential of STAT6