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In one of the studies, it was emphasized that cortisol and cortisone concentrations were higher in the morning between 04.00 and 10.00 (2.97 ng/ml and 4.88 ng/ml), in the afternoon (1.20 ng/ml and 3.54 ng/ml), in the evening (0.69 ng/ml and 2.13 ng/ml) and at night (1.59 and 3.27 ng/ml) [50]

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Deleting CCM3 protein in monolayers of human endothelial cells induced internalization of TJs proteins and diminished interactions with the actin cytoskeleton (Stamatovic et al., 2015)